There were multiple widespread polypoid lesions in the entire gastrointestinal tract, with ileocecal masses. Primary gastrointestinal tcell lymphoma resembling. In addition, immunohistochemical analysis of the biopsy tissues demonstrated positive staining for cd20, cd5, bcl 2, cd43 and mantle cell lymphoma with multiple lymphomatous polyposis and intussusception. Multiple lymphomatous polyposis mlp is an uncom mon type of primary nonhodgkin gastrointestinal gi b cell lymphoma characterized by the presence of. Colonoscopy with multiple polypoid lesions ranging from 0. Lymphomatous definition of lymphomatous by medical. The differential diagnoses of multiple lymphomatous polyposis includes adenomatous polyps, with or without carcinomatous degeneration, familial polyposis and syndromes of peutzjeghers and nodular. Approximately 60 cases of mlp have been reported so far. A patient with this condition who achieved a complete remission with combination chemotherapy is reported.
Multiple lymphomatous polyposis overexpressing cyclin d1. Pdf multiple lymphomatous polyposis ibrahim arslan. Multiple lymphomatous polyposis mlp is a distinctive type of primary gastrointestinal lymphoma characterized by polypoid accumulations of lymphoma tissue involving long segments of the gastrointestinal tract. Asymptomatic multiple lymphomatous polyposis identified during. Multiple lymphomatous polyposis mlp is an uncommon disease that is regarded as the gastrointestinal form of mcl. Primary gastrointestinal tcell lymphoma resembling multiple. These findings confirmed the diagnosis of multiple lymphomatous polyposis of the gastrointestinal tract, which was first proposed by cornes in 1961. Gastrointestinal multiple lymphomatous polyposis is a rare type of malignant lymphoma that has aggressive biological behavior, early. The histopathology in both cases was diffuse poorly differentiated lymphoma. Multiple lymphomatous polyposis with diffuse involvement. The commonest gastrointestinal gi manifestation is multiple lymphomatous polyposis, in which multiple lymphoid polyps are present in the gi.
Multiple lymphomatous polyposis of the intestine with ileocecal. Extensive colorectal lymphomatous polyposis complicated by. Multiple lymphomatous polyposis of the gastrointestinal tract. The condition has a characteristic pathological appearance and immunophenotype which is important in allowing distinction from other less aggressive forms of gastrointestinal. It is characterized by a particular involvement of the gastrointestinal tract in which long segments are the location of numerous.
Gastrointestinal multiple lymphomatous polyposis is a rare type of malignant lymphoma that has aggressive biological behavior, early systemic. Multiple polypoid masses of the distal ileum were identified in the right hemicolectomy. Multiple lymphomatous polyposis of the gastrointestinal tract scielo. A rare presentation of multiple lymphomatous polyposis with.
There was no particular history except an episode of upper gi ugi bleeding 25 years ago. Multiple lymphomatous polyposis of the gastrointestinal tract multiple lymphomatous polyposis of the gastroin testinal tract has been reported rarely. Multiple lymphomatous polyposis is an uncommon but distinctive form of gastrointestinal lymphoma. Multiple lymphomatous polyposis of the gastrointestinal tract can be associated with the bcell lymphoma variant, mantle cell lymphoma, with most cases having been described in patients who are more than 50 yearsofage. We report an unusual case of a patient with multiple. Multiple lymphomatous polyposis originates from the mantle zone of the lymphoma follicle and is considered to be a mantle cell lymphoma, which is a relatively aggressive type of bcell nonhodgkins lymphoma. Multiple lymphomatous polyposis definition of multiple. Multiple lymphomatous polyposis of the gastrointestinal. Multiple lymphomatous polyposis and the role of fine. Mantlecell lymphoma multiple lymphomatous polyposis of the. Mantle cell lymphoma presenting as multiple lymphomatous. Multiple lymphomatous polyposis mlp is an uncommon type of primary nonhodgkin gastrointestinal gi bcell lymphoma characterized by the presence of multiple polyps along the gi tract. An extensive histopathologic and immunohistochemical study of 12 cases. Extensive colorectal lymphomatous polyposis complicated by acute.
A study of four cases of mlp has shown a tendency for ileocaecal involvement and extra. Multiple lymphomatous polyposis lp is a rare entity, characterized by multiple polypoid tumors involving several segments of the gastrointestinal tract. Histologically, benign lymphoid hyperplasia is the entity most likely to be confused with lymphomatous polyposis. This is a rare gastrointestinal nonhodgkin lymphoma forming numerous polyps. Multiple intestinal lymphomatous polyposis in a jindo dog.
A unique presentation of primary intestinal malt lymphoma as. We report two rare cases of multiple lymphomatous polyposis of the gastrointestinal tract. Gi symptoms include pain, obstruction, diarrhea, or hematochezia. Multiple lymphomatous polyposis form is common but not specific for mantle cell lymphoma in the gastrointestinal tract. A rare case of multiple lymphomatous polyposis with. Alkpositive anaplastic large cell lymphoma presenting. Sep 10, 2014 the ileocecal region is the commonest site involved. Multiple lymphomatous polyposis was detected by endoscopy.
We present a typical case diagnosed by using an intestinal barium followthrough and ct scan which revealed gastric, ileac and colonic involvement as well as retroperitoneal. In this large retrospective series of 12 pa tients with lp, histologic and immunohistochemical fea tures. However, multiple lymphomatous polyposis is an uncommon. A 78 years old patient was admitted to our department of general surgery with rectal bleeding, abdominal pain and weight loss. The lymphoma is of centrocytic type and exhibits a nodular pattern of. Multiple lymphomatous polyposis of the gastrointestinal tract department of pathology and department of gastroenterological surgery, hospital do servidor publico estadual, sao paulo, brazil context. This rare entity has been recently reclassified as mantle cell lymphoma. Multiple lymphomatous polyposis is a distinctive and particularly rare clinical type of malignant gastrointestinal lymphoma, which is classified as bcell centrocytic nonhodgkins lymphoma. The subsequent workup included a thoracoabdominopelvic computed tomography ct scan that revealed thickening of several segments of the small and large intestinal walls, most prominent in the terminal ileum, multiple mesenteric adenopathies and homogeneous hepatosplenomegaly.
Cell proliferation may be nodular or diffuse with a mixed nodular pattern. Alkpositive anaplastic large cell lymphoma presenting multiple lymphomatous polyposis. Methods a 78 years old patient was admitted to our department of. Multiple lymphomatous polyposis is a rare form of gastrointestinal lymphoma characterized by the presence of multiple polyps throughout the length of the digestive tract. A rare case of multiple lymphomatous polyposis due to mantle cell lymphoma is reported in a 34yearold man. Multiple lymphomatous polyposis lp is a rare entity, characterized by multiple polypoid tu mors involving several segments of the gastrointestinal tract. Only 4% of intestinal lymphomas result in polyposis. Diffuse large bcell lymphoma presenting as multiple. Pdf multiple lymphomatous polyposis mustafa benekli. We report the first case of diffuse large bcell lymphoma presenting as multiple lymphomatous polyposis of the gi tract in a 49yearold patient with hiv and describe the clinicopathologic features. Ileocecal resection was performed on immunohistochemical. Sep 16, 20 the gastrointestinal tract is the predominant site of appearance of extranodal nonhodgkin lymphomas. Pdf mantle cell lymphoma presenting as multiple lymphomatous.
Patients range from 37 to 83 years of age, with a male predominance. It is characterized by multiple polypoid lesions involving long gastrointestinal tracts and it accounts for only approximately 12% of nonhodgkin lymphomas. A second colonoscopic examination performed in july 2004 revealed increased numbers of polyps, indicating a case of multiple lymphomatous polyposis mlp. Multiple lymphomatous polyposis financial definition of.
Multiple lymphomatous polyposis mlp is an uncom mon type of primary non hodgkin gastrointestinal gi b cell lymphoma characterized by the presence of. Multiple lymphomatous polyposis mlp is thought to be a typical form of gastrointestinal lesion in mantle cell lymphoma, but it develops in other bcell lymphomas. He received daily 100 mg of aspirin, enalapril maleate. Pdf multiple lymphomatous polyposis of the gastrointestinal. The gastrointestinal tract is the predominant site of appearance of extranodal nonhodgkin lymphomas. Ileocecal resection was performed on immunohistochemical examination, the. Multiple lymphomatous polyposis is a rare type of gastrointestinal lymphoma that extensively infiltrates the intestine. One case had multiple relapses despite treatment and died after 58 months. Multiple lymphomatous polyposis article about multiple. Primary nonhodgkins lymphoma nhl of the gastrointestinal gi tract is the most common extranodal nhl and accounts for 4%20% of all nhl. Lymphomatous definition of lymphomatous by the free dictionary.
A master limited partnership allows limited partners to buy and sell units of the. Mantlecell lymphoma multiple lymphomatous polyposis of the entire gi tract a 65yearold white man was admitted at to the emergency room with melena of moderate severity in may 2005. In fact tumor cells, typically, express cd20 or cd5 and cyclin d1 markers in these conditions. Pdf colonic mantle cell lymphoma with multiple lymphomatous. Lymphomatous polyposis lp is a distinct clinicopathologic condition. In this large retrospective series of 12 patients with lp, histologic and immunohistochemical features were investigated from patients with multiple biopsy samples from each site. Biopsy was performed again to confirm the diagnosis of colonic mcl. Mantle cell lymphoma with multiple lymphomatous polyposis. Exhaustive staging and immunohistochemical analysis were performed.
Multiple lymphomatous polyposis is thought to represent mantle cell lymphoma of the gi tract. From 1984 to 1995, 31 patients were enrolled prospectively. Saito m, izumiyama k, ogasawara r, mori a, kondo t, tanaka m, morioka m, miyashita k, tanino m. Multiple lymphomatous polyposis mlp is a type of manifestation of mantle cell lymphoma mcl and it is characterized by multiple polypoid lesions involving long segments of the gastrointestinal tract and it accounts for only approximately 12% of non hodgkin lymphomas. Lymphomatous definition of lymphomatous by the free.
Arch pathol lab medvol 127, august 2003 multiple lymphomatous polyposisremestroche et al 1029 figure 1. Multiple lymphomatous polyposis mlp is an uncommon type of gastrointestinal lymphoma. Extranodal involvement of the gi tract is a wellrecognized entity of mantle cell lymphoma. Pathology outlines mantle cell lymphoma, classic variant. Multiple lymphomatous polyposis can present with diverse clinical symptoms including abdominal pain, diarrhea, bleeding, proteinlosing. Despite prompt remission, prognosis remains poor in view of increased relapse rates. Multiple lymphomatous polyposis mlp is uncommon and is regarded as the intestinal form of mcl. Multiple lynphomatous polyposis is a type of appearance of mantle cell lymphoma. Multiple lymphomatous polyposis with diffuse involvement of. The ileocecal region is the commonest site involved. In this large retrospective series of 12 pa tients with lp, histologic and immunohistochemical fea tures were investigated from patients with multiple bi.
Lymphomatous definition of lymphomatous by medical dictionary. Multiple lymphomatous polyposis of the intestine with. A limited partnership consists of a general partner, who manages the venture, and limited partners, who simply provide capital. As primary tumor, malignant lymphoma accounts for 0. Mantle cell lymphoma with multiple lymphomatous polyposis and. Complete response in a patient with colonic mantle. Gi polyposis occurs in up to 10% of cases, including conditions such as multiple lymphomatous polyposis mlp and immunoproliferative. Multiple lymphomatous diverticulosis and comorbid chronic.
A case of mantle cell lymphoma mcl associated with multiple lymphomatous polyposis mlp is reported is a 62yearold woman, with special reference to the patients clinical features and response to treatment. Small bowel followup examination with barium shows multiple smooth and round. Multiple biopsies of the complete gi tract presented diffuse infiltration of monotonous smalltomedium sized, lymphoid cells. Malignant cells of mlp have mantle cell characteristics and thus are considered to be the counterpart of the mantle cell lymphoma mcl in the gi tract. We report a rare case of multiple lymphomatous polyposis of the gastrointestinal tract in which the patient presented with abdominal pain and bloody diarrhea. Mantle cell lymphoma mcl has tropism for the gastrointestinal tract git identifiable as multiple polyps and mass lesions throughout the git. Morphological and immunohistochemical studies are essential for diagnosis of mlp. Mantlecell lymphoma multiple lymphomatous polyposis of.
Multiple lymphomatous polyposis is a specific type of lymphomas. Most cases occur at multiple sites from oesophagus to rectum. A micronodular pattern of splenic involvement are seen in both mantle cell lymphoma and splenic marginal zone lymphoma villous cells in pb may be seen in mantle cell lymphoma mantle cell lymphoma expresses cd5 and cyclin d1. Multiple lymphomatous polyposis of the gastrointestinal tract article pdf available in sao paulo medical journal 1223. Mantlecell lymphoma multiple lymphomatous polyposis. We report a rare case of multiple lymphomatous polyposis of the gastrointestinal tract in which the patient. A 60yearold woman with known chronic lymphocytic leukemia cll had an exophytic mass of the appendiceal orifice. Meeting abstract open access multiple lymphomatous. Multiple lymphomatous polyposis is a distinctive and rare type of malignant gi lymphoma.
A unique presentation of primary intestinal malt lymphoma. Clinical symptoms may closely resemble those of colorectal carcinoma and diagnostic confusion may result. A rare case of multiple lymphomatous polyposis with widespread. Master limited partnership master limited partnership a limited partnership with ownership units that may be traded on an exchange. Multiple polypoid masses of the distal ileum were identified in the right hemicolectomy specimen multiple lymphomatous polyposis. Sep 22, 2016 multiple lymphomatous polyposis mlp is uncommon and is regarded as the intestinal form of mcl. Multiple lymphomatous polyposis of the colon and rectum. Clinical features, family history, and histology usually distinguish these conditions. Multiple lymphomatous polyposis mlp as an extranodal manifestation of mantle cell lymphoma mcl in the. Multiple lymphomatous polyposis may also be seen in marginal b cell lymphomas, mucosa associated lymphoid tissue malt, and follicular lymphomas. Endoscopic mucosal resections were performed on lesions and the resected specimens suggested mantle cell lymphoma mcl. The aim of this study was to analyze the clinicopathologic features and outcome of a large series of patients. Multiple lymphomatous polyposis is considered to be a rare condition, with most of the cases being extranodal counterpart of mantle cell lymphomas. The gastrointestinal tract is the predominant site of extranodal nonhodgkin lymphomas.
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